Mitochondria and Cytoprotection
نویسندگان
چکیده
1 Inserm UMR-S 769, LabEx LERMIT, Châtenay-Malabry, F-92296, France 2University Paris-Sud, Châtenay-Malabry, F-92296, France 3 Inserm UMR 676, Hôspital Robert Debré, F-75019 Paris, France 4Faculté de Médecine Denis Diderot, Université Paris 7, IFR02, F-75019 Paris, France 5Faculty of Medicine, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
منابع مشابه
A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes
Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury. There is evidence [Malouitre, Dube, Selwood and Crompton (2010) Biochem. J. 425, 137-148] that cytoprotection by the CyP inhibitor CsA (cyclosporin A) is improved by selective targeting to mitochondria. To investigate this furt...
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عنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012